Scooby-Doo! Mystery Incorporated (also known as Mystery Incorporated or Scooby-Doo! Mystery, Inc.) is the eleventh incarnation of Hanna-Barbera's Scooby-Doo animated series, and the first incarnation not to be first-run on Saturday mornings. The series is produced by Warner Bros. Animation and Cartoon Network and premiered in the United States on Cartoon Network on April 5, 2010, with the next twelve episodes continuing, and the first episode re-airing, on July 12, 2010. The series concluded on April 5, 2013 with two seasons and fifty-two episodes, with a total of twenty-six episodes per season. By episode count, this is the longest running Scooby-Doo series to date.
Mystery Incorporated returns to the early days of Scooby and the gang, when they are still solving mysteries in their home town, though it makes many references to previous incarnations of the franchise, not least among them many cases and creatures from the original [[Scooby-Doo, Where Are You![[. Episode by episode, the series takes a tongue-in-cheek approach to the classic Scooby-Doo formula (similar to A Pup Named Scooby-Doo and Shaggy & Scooby-Doo Get a Clue!), with increasingly outlandish technology, skills and scenarios making up each villain's story, and a different spin on the famous "meddling kids" quote at the end of every episode. Contrasting sharply with this, however, are two elements that have never been used in a Scooby-Doo series before: a serial format with an ongoing story arc featuring many dark plot elements that are treated with near-total seriousness, and ongoing relationship drama between the characters.
The series pays extensive homage to the horror genre, drawing on many works from film, television and literature in both parodic and serious ways, from horror movie classics like A Nightmare on Elm Street, modern films such as Saw, television series Twin Peaks, and the works of H. P. Lovecraft, alongside the classic monster horror movies shown in previous series. In particular, in the second season, the central story arc of the show evolves to heavily feature the use of Babylonian mythology, exploring the Anunnaki, the Babylonian and modern pseudo-scientific concepts of Nibiru, and the writings of Zecharia Sitchin. Other Hanna-Barbera characters occasionally guest-star, including Captain Caveman, Jabberjaw, Speed Buggy, The Funky Phantom, Blue Falcon and Dynomutt, and more.
As was the case with the previous three installments in the franchise, Mystery Incorporated redesigns the main characters, this time into a retro look that returns them to their original 1969 outfits, with some small changes (such as Velma now wearing bows in her hair). The series is also the animated debut of Matthew Lillard as the voice of Shaggy, after he portrayed the character in two live-action films, Scooby-Doo (2002) and Scooby-Doo 2: Monsters Unleashed (2004). Casey Kasem, the original voice of Shaggy, voiced Shaggy's father. Linda Cardellini, who played Velma in the live-action movies, voiced Hot Dog Water, a recurring character in the series.